Police were called to Beaufort Street/Battersea Bridge Road at 0641hrs this morning, Wednesday, 4 October after reports of a crash between a Toyota Prius and a Honda motorcycle.
A 35-year-old man has been pronounced dead at the scene.
Next of kin have yet to be informed.
Formal identification and a post-mortem examination will held in due course.
The driver of the Toyota Prius stopped at the scene.
No arrests have been made and enquires continue.
Local road closures are in place and motorists are strongly advised to avoid the area where possible.
Anyone who witnessed the incident or has any information is asked to contact police on 101.